2025/2026 RxPrep NAPLEX Course Book Mnemonics and Pearls
Helpful and pertinent mnemonics and pearls gathered from the RxPrep 2023 version of the
NAPLEX Course Book.
Pearl - Amide- vs. Ester-Type Anesthetics - ANS-Amide-type anesthetics can be
recognized by the "i" in their name before the"-caine" ending (e.g., lidocaine,
bupivacaine, mepivacaine, ropivacaine). Ester-type anesthetics do not contain an "i"
before the "-caine" ending (e.g., procaine,
benzocaine, cocaine, tetracaine).
Hypersensitivity to one type of drug in an anesthetic class, such as the ester-type
procaine, does not confer cross-reactivity to drugs within the opposite anesthetic class,
such as the amide-type lidocaine.
Mnemonic - SLUDD - ANS-Parasympathetic Nervous System Physiologic Response
Salivation
Lacrimation
Urination
Defecation
Digestion
Mnemonic - G-PACMAN - ANS-Common CYP- Inhibitors Involved in Drug Interactions
Grapefruit
Protease Inhibitors (especially ritonavir)
Azole Antifungals (fluconazole, itraconazole, ketoconazole, voriconazole, etc.)
Cyclosporine, cobicistat
Macrolide Antibiotics (clarithromycin, erythromycin, not azithromycin)
Amiodarone (and dronedarone)
Non-DHP CCBs (verapamil, diltiazem)
Mnemonic - PS-PORCS - ANS-Common CYP- Inducers Involved in Drug Interactions
Phenytoin
Smoking
Phenobarbital
Oxcarbazepine
Rifampin, rifabutin, rifapentine
Carbamazepine
St. John's wort
Mnemonic - Salty Buns & Pot of Coffee with Cream and Sugar - ANS-Stick Diagram for
BMP
Na Cl BUN
Glucose
K HCO3 SCr