566- Unit 3- Disorders of the Hip Exam Review 2024 A+
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1. what happens to your
cells with aging?
2. articular cartilage damage to OA
3. Your patient is a 52 yo
male with a history that
leads you to a primary hypothesis of L hip
OA. However, during your
exam you note that his L
One is that our proteoglycan aggregation goes
down. The size of the glycosaminoglycans complexes also goes down.
Our proteoglycan synthesis is reduced, and those
things combined lead to a reduction in the matrix
structure of the articular cartilage and the decreased ability of that cartilage to attract fluid. Of
course, fluid and then water is a lot of where the
compressive and tensile stiffness of the cartilage
comes from. So if we're attracting less fluid, we
have less stiffness of the cartilage.
If we get just more water in there and less
healthy glycosaminoglycans complexes, the hydraulic pressure of that articular cartilage is going
to also decrease. And what we end up with with
aging is literally articular cartilage that is not as
strong as the cartilage in younger folks.
Therefore, slowly evolving articular disease that
appears to originate in the articular cartilage is
going to also affect the underlying bone and soft
tissues-- this is osteoarthritis