In Alzheimer's disease, neuron loss occurs throughout the brain. However, the greatest loss is in which of the following areas? A. medial temporal lobe B. anterior parietal lobe C. medial occipital lobe D. posterior frontal lobe The medial temporal lobe includes the entorhinal cortex, amygdala, and hippocampus, which are involved in memory and are most affected by Alzheimer's disease. Functional brain imaging of a patient with mild-to-moderate Alzheimer's disease is most likely to find which of the following? A. increased metabolism in the frontal lobes and basal ganglia B. decreased metabolism in the prefrontal cortex and thalamus C. reduced metabolism in the hippocampus and entorhinal cortex D. increased metabolism in the hippocampus and amygdala Neuronal degeneration in the medial temporal structures (entorhinal cortex, hippocampus, and amygdala) has been linked to Alzheimer's disease. On a PET scan, this is manifested as reduced metabolism in these structures. Research on the effectiveness of the SSRIs has found that: A. a higher dose of an SSRI is usually required when treating OCD than when treating depression. B. a lower dose of an SSRI is usually required when treating OCD than when treating depression. C. a moderate dose of an SSRI is usually required when treating OCD but the correct dose for depression depends on the severity of symptoms. D. a moderate dose of an SSRI is usually required when treating depression but the correct dose for OCD depends on the severity of symptoms. The research on SSRI dosage is limited and not entirely consistent. However, based on their meta-analysis of the studies, H. Bloch and colleagues concluded that a higher dose is required when treating OCD
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