1. A healthcare provider prescribes cephalexin monohydrate (Keflex) for a client with a postoperative infection. It is most important for the nurse to assess for what additional drug allergy before administering this prescription?

A) Penicillins.

B) Aminoglycosides.

C) Erythromycins.

D) Sulfonamides.

A) Penicillins

Cross-allergies exist between penicillins (A) and cephalosporins, such as cephalexin monohydrate (Keflex), so checking for penicillin allergy is a wise precaution before administering this drug.

2. Which nursing intervention is most important when caring for a client receiving the antimetabolite cytosine arabinoside (Arc-C) for chemotherapy?

A) Hydrate the client with IV fluids before and after infusion.

B) Assess the client for numbness and tingling of extremities.

C) Inspect the client's oral mucosa for ulcerations.

D) Monitor the client's urine pH for increased acidity.

C) Inspect the client's oral mucosa for ulcerations.

Cytosine arabinoside (Arc-C) affects the rapidly growing cells of the body, therefore stomatitis and mucosal ulcerations are key signs of antimetabolite toxicity (C). (A, B, and D) are not

typical interventions associated with the administration of antimetabolites.