What quantity of Compound 1 (483.5g) must be provided to prepare 100.00 mL of solution with a concentration equal to Ki (60.3uM)? M=mol/v 1 umol=0.000001 moles (1x10^-6) 2.92mg If only [I] is increased, then [ESI] or [EI] increases. This is an example of: A. the Bose-Einstein Principle. B. the Heisenberg Uncertainty Principle. C. the Le Châtelier's Principle. D. the Pauli Exclusion Principle. Solution: The correct answer is C. A. The Bose-Einstein Principle states that a collection of atoms cooled close to absolute zero will coalesce into a single quantum state. B. The Heisenberg Uncertainty Principle states that one cannot know both the momentum and position of an object with absolute certainty. C. Le Châtelier's Principle states that in a reversible process, the application of stress to the system will cause the system to respond in a way that will relieve this stress. In this case, the reversible process is E + I forming EI or ES + I forming ESI. In either case, increasing [I] induces stress of the system, and the system relieves that stress by converting I to either more EI or ESI. D. The Pauli Exclusion Principle states that two or more identical fermions, e.g. electrons, cannot occupy the same quantum state. Which structural change to Compound 1 would make it more water soluble? A. Replacing benzene CH with N in the ring B. Replacing C=O with C=CH2 C. Replacing N-N=N with CH-CH=CH D. Replacing NH with NCH3 Solution: The correct answer is A. A. Nitrogen in the benzene ring would have a lone pair that could accept a hydrogen bond from water, thus increasing the solubility of the compound. B. Replacing C=O with C=CH2 would decrease the polarity of the compound and make it less water soluble. C. Replacing N−N=N with CH−CH=CH would decrease the polarity of the compound and make it less water soluble. D. Replacing NH with NCH3 removes a hydrogen bond donor, thus decreasing water