MICRO160 EX4A FALL 2020 Somatic gene therapies for HIV treatment would produce a genetically modified immune system by removing the gene. The goal is to create an immune system like the “Berlin patient’s” which . (A) CD4, will destroy HIV (B) gp120, allows viral replication (C) CCR5, some HIV viral types cannot infect (D) CD4, destroys all CD4 cells and keeps viral loads low 2. New HIV infections have dropped by over 50% in 25 countries since 2008. This is largely due to reduction in which type of transmission? (A) Men having sex with men (C) Intravenous drug use (B) Blood transfusions (D) Mother to child transmission 3. Recent discoveries have described new immunity to retroviral (SIV) infection in several different types of monkeys. This immunity comes from a(n) arrangement of genes coding for proteins which detect . (A) existing, bacterial cell wall (C) old, innate immunity receptors (B) novel/new, viral capsid (D) old, host RNA 4. Which of the following is NOT a reason why more HIV+ people are in treatment. (A) poverty (B) denial (C) apathy (D) better health insurance 5. Which of the following are barriers to lowering HIV infections worldwide? (A) medical illiteracy (C) poverty (B) lack of an effective vaccine (D) all of the above 6. Uganda’s ABC-abstinence program to lower HIV infection rates ultimately failed because? (A) ARV drugs weren’t available (C) people didn’t follow it (B) most viruses mutated (D) A,B and C 7. Bone Marrow transplants from R5 negative donors has been tried since success of The Berlin Patient, most of these patients died. Which of the following has NOT been found to be a cause of these deaths. (A) R4 tropic virus breakout (C) secondary infection (B) radiation induced lymphoma (D) R5 virus rebound 8. Advances in antiretroviral therapies have increased HIV positive life expectancy, particularly in wealthy countries. However, life expectancy has NOT increased even with better drugs for . (A) intravenous drug users (B) patients who start drugs with low CD4 counts (D) both A and B (C) Men who have sex with men (