Chapter 1 2. The manifestations of a disease are best defined as the: a. subjective feelings of discomfort during a chronic illness. b. signs and symptoms of a disease. c. factors that precipitate an acute episode of a chronic illness. d. early indicators of the prodromal stage of infection. b. signs and symptoms of a disease. 6. A type of cellular adaptation in which there is a decrease in cell size is referred to as: a. hypertrophy. b. metaplasia. c. anaplasia. d. atrophy. d. atrophy. 7. A change in a tissue marked by cells that vary in size and shape and show increased mitotic figures would be called: a. metaplasia. b. atrophy. c. dysplasia. d. hypertrophy. c. dysplasia 10. Rigorous weight lifting/body building regimens may result in the skeletal muscle cells undergoing: a. hypertrophy. b. dysplasia. c. atrophy. d. regeneration. a. hypertrophy 12. To which of the following does the term apoptosis refer? a. Increased rate of mitosis by certain cells b. Ischemic damage to cells c. Liquefaction of necrotic tissue d. Preprogrammed cell self-destruction d. Preprogrammed cell self-destruction 13. Routine application of sun block to skin would be an example of: a. an iatrogenic cause of cancer. b. a preventive measure. c. a precipitating factor. d. a predisposing condition. b. a preventive measure 19. Pathophysiology involves the study of: a. the structure of the human body. b. the functions of various organs in the body. c. functional or structural changes resulting from disease processes. d. various cell structures and related functions. c. functional or structural changes resulting from disease processes. Chapter 2 8. Which of the following is a typical sign of dehydration?