Chapter 14. Drugs Affecting the Autonomic Nervous System

____ 1. Which of the following drugs used to treat Alzheimer’s disease is not an anticholinergic?

1. Donepezil

2. Memantine

3. Rivastigmine

4. Galantamine

____ 2. Taking which drug with food maximizes it bioavailability?

1. Donepezil

2. Galantamine

3. Rivastigmine

4. Memantine

____ 3. Which of the following drugs should be used only when clearly needed in pregnant and breastfeeding women?

1. Memantine

2. Pyridostigmine

3. Galantamine

4. Rivastigmine

____ 4. There is a narrow margin between first appearance of adverse reaction to AChE inhibitors and serious toxic effects. Adverse reactions that require immediate action include:

1. Dizziness and headache

2. Nausea

3. Decreased salivation

4. Fasciculations of voluntary muscles

____ 5. Adherence is improved when a drug can be given once daily. Which of the following drugs can be given once daily?

1. Tacrine

2. Donepezil

3. Memantine

4. Pyridostigmine

____ 6. Nicotine has a variety of effects on nicotinic receptors throughout the body. Which of the following is NOT an effect of nicotine?

1. Vasodilation and decreased heart rate

2. Increased secretion of gastric acid and motility of the GI smooth muscle

3. Release of dopamine at the pleasure center

4. Stimulation of the locus coeruleus

____ 7. Nicotine gum products are:

1. Chewed to release the nicotine and then swallowed for a systemic effect

2. “Parked” in the buccal area of the mouth to produce a constant amount of nicotine release

3. Bound to exchange resins so the nicotine is only released during chewing

4. Approximately the same in nicotine content as smoking two cigarettes

____ 8. Nicotine replacement therapy (NRT):

1. Is widely distributed in the body only when the gum products are used

2. Does not cross the placenta and so is safe for pregnant women

3. Delays healing of esophagitis and peptic ulcers

4. Has no drug interactions when a transdermal patch is used

____ 9. Success rates for smoking cessation using NRT:

1. Are about the same regardless of the method chosen

2. Vary from 40% to 50% at 12 months

3. Both 1 and 2

4. Neither 1 nor 2

____ 10. Cholinergic blockers are used to:

1. Counteract the extrapyramidal symptoms (EPS) effects of phenothiazines

2. Control tremors and relax smooth muscle in Parkinson’s disease

3. Inhibit the muscarinic action of ACh on bladder muscle

4. All of the above