whichqantacids qhave qthe qhighest qabsolute qneutrophil qcount q(ANC)? - sodiumqbicarbonate qandqcalciumqcarbonate What qdoqcalciumqcontaining qantacids qneeds qfor qabsorption? - vitaminqD AntacidqIndications - hyperacidity, PUD, qGERD, qCalciumqdeficiency, qChronic qRenal qfailure, qosteoporosis qprevention What qis qthe q1st qline qtherapy qfor qGERD? - H2 qblockers qandqPPIs AntacidqADRs - Mg-diarrhea aluminumq&qCa=constipation Antacids: qDrug qInteractions - Adsorptionqof qother qdrugs qtoqantacids: Reduces qthe qability qof qthe qother qdrug qtoqbe qabsorbedqintoqthe qbody=separateqadministrationqby q2 qhours antacidqpatient qeducation - symptoms q> qthanq2 qweeks, extreme qpain, qcramping, qor qbloodqinqstool=call qprovider lifestyle qchangedqtoqprevent qGERDqsymptoms - stopqsmoking increase qHOBqwhile qsleeping noqspicy qfood, qnoqalcohol, qnoqfatty qfoods, qnoqchocolate, qnoqcaffeine Antidiarrheal qclasses - opiates qabsorbents qanticholinergic sqCrofelemer Absorbent qantidiarrheals qdrugs - Kaolin qpectin Bismuthqsubsalicylate q(Pepto-Bismol) q; quse qwithqeachqloose qstool opiate qantidiarrheals qdrugs - Diphenoxylate qwithqatropine q(Lomotil)qDiphenoxinqwithqatropine q(Motofen) qLoperamide q(immodium) anticholinergic qantidiarrheals qdrugs - atropine qpropanthelin e what qcauses qmost qdiarrhea? - infection, qfoodqor qdrug qingestions, qor qinflammatory qbowel qdisease KaolinqMOA - attracts qandqholds qonqtoqbacteria pectinqMOA - thickens qstool BismuthqSubsalicylate qMOA - antisecretory q&qantimicrobial qeffects Lomotil q(diphenoxylate/atropine) qMOA - decreases qbowel qsecretions qandqperistalsis motofenq(difenoxin/atropine) qMOA - decreases qbowel qsecretions qandqperistalsis Loperamide q(Imodium) qMOA - Decreases qGI qmotility; qbinds qtoqopioidqreceptors Crofelemer q(Fulyzaq) qindication - diarrhea qinqpatient qwithqHIV/AIDS qwhoqare qtaking qantivirals antidiarrheal qprecautions/contraindications - opioids: qtoxic qmegacolon pepto: qdoqnot quse qinqchildrenqwithqflu-like qillnessqcontraindicatedqinqmost qchildren cautionqinqpts qwithqhepatorenal qdisease antidiarrheal qADRs - constipation bismuth=black qtongue, qgray/black qstoolqanticholinergic qeffects CNS qeffects antidiarrheal qdrug qinteractions - ASA: qincreasedqrisk qfor qsalicylate qtoxicity insulinqor qoral qDMqmeds: qincreasedqrisk qfor qhypoglycemiaqthrombolytics: qincreasedqrisk qfor qbleeding lomotil q&qimmodium: qincreasedqCNS qdepressionqwithqalcohol qandqanticholinergic qeffectsqwithqother qanticholinergics qdrugs Laxative qclasses - stimulants qosmotics bulk-producing qlaxativesqlubricants surfactants qhyperosmolar qlaxatives chloride qchannel qactivators qopioidqreceptor qantagonists laxative qstimulant - cascara qsenna qbisacody l castor qoil; qstimulate qmyenteric qplexus; qrapidqacting, qshort qterm Osmotic qlaxatives - Mg qhydroxideqMg qcitrate Na qphosphate polyethlyene qglycol qelectrolyte qsolution polyethlyene qglycol q(PEG) q3350; qdrawqwater qintoqintestinal qlumen Bulk qproducing qlaxative - Psyllium methyl qcellulose polycarbophil; qmixes qwithqwater qinqintestine; qslowqresponse, qlong-term; qolder qadults Lubricant qlaxatives - mineral qoil; qsoftenqstool, qlubricates qintestine surfactant qlaxative - docusate qcompounds q(Colace); qreduce qsurface qtensionqonqthe qoil qwater qinterface qon qtheqstool q&qfacilitate qa qmixture qof qfat q&qwater qintoqthe qstool hyperosmolar qlaxative - glycerine laculose; qdraws qwater qintoqintestines Chloride qchannel qactivators qdrugs - lubiprostone q(Amitiza); qsoftenqstools qandqincreases qGI qmotility; qchoric qidiopathicqconstipation, qIBS, qopioidqinducedqconstipation Opioidqreceptor qantagonists’ qdrugs - methylnaltrexone; qantagonist qinqthe qmu-receptor qinqthe qGI qtrack; qopioid qinducedqconstipation laxative q1st qline qtherapy - stimulants Laxatives qare qcontraindicatedqin - N/v undiagnosedqabd qpainqbowel qobstruction Renal qdysfunctionq(Mg qhydroxide) laxative qprecautions - abuse qand q dependency qcathartic qcolon=ulcerative qcolitis tartrazine qsensitivity=allergic qreactions=asthma Cytoprotective qagents - sucralfate q(Carafate) misprostol q(Cytotec); qtx qPeptic qulcers qcausedqby qNSAIDquse Clinical qPearl qfor qpolyethylene qglycol qelectrolyte qsolution - salty qtaste; qplace qonqice qinqBasin; qdrink q240 qml/10 qmins; qtic qtac qor qhardqcandy qreducesqsalty qtaste Sucralfate q(Carafate) - Adheres qto qinjured qgastric qulcers qupon qcontact qwith qgastric qacids; q. qUsed qfor qgastric qandqduodenal qulcers qandqGERD. qAdminister qon qan qempty qstomach qat qleast qone qhour qbefore qmeals qand qat qHS qand qdo qnot qadminister qwithin q30 qminutes qof qantacids.; quse qfor q8 qweeks Misprostol q(Cytotec) - inhibits qgastric qsecretion, qmucosal qprotection; qanalog qof qprostaglandinqE1; qprophylaxis qfor qduodenal qulcers qdue qtoqNSAIDS qor qfor qthose qthat qmust quse qNSAIDS; qonly qtake qduringqNSAIDqtherapy!; qtake qwithqfood