1. Immunosuppressants do what?: Answer Drugs used to inhibit immune response 2. Immunosuppressants uses: Answer •Used for patients who have received an organ/tis-sue transplant - Transplanted organs always contain some antigens that trigger immune response - Antibodies can destroy transplanted tissue within a few days • Drugs also used for patients who have an autoimmune disorder • Severe cases of rheumatoid arthritis • Lupus • Multiple Sclerosis 3. Agents used for Immunosuppression:: Answer • Calcineurin Inhibitors • Glucocorticoids • Cytotoxic Agents 4. Calcineurin Inhibitors Characteristics: Answer Most effective immunosuppressantsavailable: • Used primarily to prevent rejection of kidney, liver and heart transplant 5. Calcineurin Inhibitors Metabolism is inhibited by: Answer grapefruit juice æ Greatly increases risk of toxicity