1. Pharmacokinetics: Answer what the body does to the drug (absorption, distribution,metabolism, excretion) 2. Bioavailability: Answer issues important for drugs with narrow therapeutic ranges orsustained release mechanism 3. Half-life: Answer time required for amount of drug in body to decrease by 50% 4. First Pass Effect (Metabolism): Answer rapidly metabolized by liver, may have little ifany desired action 5. Adverse drug reaction: Answer - any unexpected, unintended, undesired, or excessiveresponse to a medication given at therapeutic dosages (as opposed to overdose) - infants/young children: lack of studies in that population - elderly: decrease in renal function - teratogen causes type D ADR (ex lisinopril)