1. Drugs that use CYP3A4 isoenzymes for metabolism may: Answer Both 1 and 2 2. Drugs that have a significant first-pass effect: Answer Are rapidly metabolized by theliver and may have little if any desired action 3. A patient's nutritional intake and lab work reflect hypoalbuminemia. This is critical to prescribing because:: Answer distribution of drugs to target tissue may beaffected 4. The route of excretion of a volatile drug will likely be:: Answer the lungs 5. The point in time on the drug concentration curve that indicatesthe firstsignof a therapeutic effect is the: Answer onset of action 6. Factors that affect gastric drug absorption include: Answer lipid solubility of the drug 7. Which one of the following statements about bioavailability is true: Answer bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained release mechanisms 8. Steady state is: