1. The major reason for not crushing a sustained release capsule is that, ifcrushed, the coated beads of the drugs could possibly result in: o Disintegration o Toxicity o Malabsorption o Deterioration: Answer o Toxicity 2. Drugs that have a significant first pass effect: o Must be given by enteral (oral) route only o Bypass the hepatic circulation o Are rapidly metabolized by the liver and may have little if any desired action o Are converted by the liver to more active in fat-soluble forms: Answer o Are rapidlymetabolized by the liver and may have little if any desired action 3. When obtaining a drug history from Harold, he gives you a complete list ofhis prescription medications. He denies taking any other drugs, but you findthat he occasionally takes aspirin for his arthritisflare-ups.Thisis an exampleof: o His appropriately only telling you about hisregularly prescribed medications o His hiding information regarding his inappropriate use of aspirin from you o His common misconception that intermittently taking OTC medications arenot an important part of his drug history o A common misuse of OTC aspirin: Answer o His common misconception that intermittently taking OTC medications are not an important part of his drug history 4. Drugs that use CYP3A4 isoenzymes for metabolism may: o Induce the metabolism of another drug o Inhibit the metabolism of another drug