A nursing student asks the nurse to explain the role of cyclooxygenase-2 (COX-2) and its role in
inflammation. The nurse will explain that COX-2
Converts arachidonic acid into prostaglandins.
Directly causes vasodilation and increased capillary permeability.
Irritates the gastric mucosa to cause gastrointestinal upset.
Inactivates bradykinins to cause inflammation and pain.
A nursing student asks how nonsteroidal antiinflammatory drugs (NSAIDs) work to suppress
inflammation and reduce pain. The nurse will explain that NSAIDs
Exert direct actions to cause relaxation of smooth muscle.
Inhibit cyclooxygenase that is necessary for prostaglandin synthesis.
Interfere with neuronal pathways associated with prostaglandin action.
Suppress prostaglandin activity by blocking tissue receptor sites.
A patient who is taking aspirin for arthritis pain asks the nurse why it also causes gastrointestinal
upset. The nurse understands that this is because aspirin
Decreases gastrointestinal secretions.
Increases hypersensitivity reactions.
Inhibits both COX-1 and COX-2.
Is an acid-base compound
A patient is taking aspirin to help prevent myocardial infarction and is experiencing moderate
gastrointestinal upset. The nurse will contact the patient’s provider to discuss changing from
aspirin to which drug?
A COX-2 inhibitor
Celecoxib (Celebrex)
Enteric-coated aspirin (Ecotrin)
Nabumetone (Relafen)
The nurse is performing a health history on a patient who has arthritis. The patient reports
tinnitus. Suspecting a drug adverse effect, the nurse will ask the patient about which medication?
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Aspirin (Bayer)
Acetaminophen (Tylenol)
Anakinra (Kineret)
Prednisone (Deltasone)
A patient who takes high-dose aspirin to treat rheumatoid arthritis has a serum salicylate level of
35 mg/dL. The nurse will perform which action?
Assess the patient for tinnitus.
Monitor the patient for signs of Reye’s syndrome.
Notify the provider of severe aspirin toxicity.
Request an order for an increased aspirin dose.
The nurse is caring for a postoperative woman who is refusing opioid analgesics but is rating her
pain as a 7 or 8 on a 10-point pain scale. The nurse will contact the provider to request an order
for which analgesic medication?
Diclofenac sodium (Voltaren)
Ketoprofen (Orudis)
Ketorolac (Toradol)
Naproxyn (Naprosyn)
A patient who has osteoarthritis with mild to moderate pain asks the nurse about taking over-thecounter ibuprofen (Motrin). What will the nurse tell this patient?
“It may take several weeks to achieve therapeutic effects.”
“Unlike aspirin, there is no increased risk of bleeding with ibuprofen.”
“Take ibuprofen once daily for maximum analgesic benefit.”
“Combine ibuprofen with acetaminophen for best effect.”
The nurse is caring for a patient who has rheumatoid arthritis and who is receiving infliximab
(Remicade) IV every 8 weeks. Which laboratory test will the nurse anticipate that this patient
will need?
Calcium level
Complete blood count
Electrolytes
Potassium
The nurse is teaching a patient about taking colchicine to treat gout. What information will the
nurse include when teaching this patient about this drug?
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Question 10
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Avoid all alcohol except beer.
Include salmon in the diet.
Increase fluid intake.
Take on an empty stomach.
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