PharmiFlashcards NERVOUSiSYSTEM Benzodiazepines • Alprazolam • Diazepam • Lorazepam • Chlordiazepoxide • Sedation • Dependency/Withdrawali-iShortiterm • AntidoteiisiFlumazenil AtypicaliAnxiolytics • Buspirone • NoiSedationi-iNoiDependencyi-iLongiterm • Fullieffectsitakeiweeks • Takeiwithimeals SSRIs • Paroxetine • Sertraline • Fluoxetine • Insomnia • WatchiforiSerotoniniSyndromei(Agitation,iHallucinations,iFever, iDiaphoresis,iTremors) • DoiNotiTakeiWithiSt.iJohn’siWort • FulliEffectsitakeimonths AtypicaliAntidepressants • Bupropion • Trazodonei(MajoriSideiEffecti-iSedation) • Depressioni&iSmokeiCessation • Insomnia,iheadache,iGIiDistress,iWeightiLoss,iAgitation,iSeizures TCAs • Amitriptyline • Imipramine • Sedation,iorthostaticihypotensioniAnticholinergiciEffectsi(Urinary iRetention,iConstipation,iDryiMouth,iBlurryiVision,iPhotophobia) MAOIs • Phenelzine • Tranylcypromine • HTNiCrisis • Doinotieatifoodsiwithityramine MoodiStabilizers • Lithium • SideiEffects:iGIiUpset,iFineiHandiTremorsi(CoarseiiniTox),iPolyuria, iWeightigain,iKidneyiTox,iElectrolyteiimbalances • MonitoriPlasmaiLevels:iToxioveri1.5imEq/L • Toxicityi(Coarseihanditremors,iconfusion,ihypotension,iseizures,itinnitus • Noidiuretics,iAnticholinergicsioriNSAIDs • ContraindicatediiniRenaliDisease • CloselyimonitoriNA,iDrinki2-3iLiofiwater Antiepilepticsi(BipolariDisorder) • Carbamazepinei(BloodiIssuesi(Anemia,iThrombocytopeniai& iLeukopenia),iVisioniIssuesi&iRash) • ValproiciAcidi(GIiUpset,iHepatotoxicity,iPancreatitis,iThrombocytopenia) Antipsychotics • Chlorpromazine • Haloperidol • EPS,iNMS,iAgranulocytosis,iAnticholinergiciEffects,iSedation • MonitoriVitalsi1-2ihours • BenztropineicanicontroliEPS • DantroleneicanicontroliNMS AtypicaliAntipsychotics • Risperidonei(IMiqi2iweeksiforinon-compliance) • Clozapinei(Agranulocytosis) • Olanzapine • Diabetes,iWeightiGain,iIncreasediCholesterol,iSedation, iAnticholinergiciEffects • AvoidiAlcohol ADHDiMeds • Methylphenidate • Amphetamine • Insomnia,iDysrhythmias,iDecreasediAppetite,iWeightiLoss • Doinotigiveiatinight • GiveiImmediatelyiBefore/AfteriMeals • MonitoriChild’siWeight AlcoholiAbusei(Withdrawal) *WithdrawaliStartsiWithini4-12iHoursiofiLastiDrink *Peaksiati24-48iHours • Benzodiazepinesi-iStabilizesivitals,iDecreaseiSeizures • Carbamazepinei-iDecreasesiSeizures • Clonidinei-iDecreasesiBPi&iHR