ANGIOTENSIN- RECEPTOR BLOCKERS

The renin-angiotensin-aldosterone system (RAAS) is an important regulator of blood pressure,

blood volume, and fluid and electrolyte levels.

Angiotensin II and aldosterone both influence the effects of the RAAS and cause pathologic

changes in heart and blood vessel tissues.

Angiotensin II is a potent vasoconstrictor and stimulates aldosterone release; both of these

actions increase blood pressure.

Angiotensin-receptor blockers (ARBs) prevent angiotensin II from binding with target

receptors, thereby blocking the actions of angiotensin II.

By blocking angiotensin II actions, ARBs help to dilate veins and arterioles, prevent

remodeling and hypertrophy of heart and blood vessel tissues, and decrease aldosterone release

to lower blood pressure.

Unlike ACE inhibitors, ARBs do not inhibit kinase II and increase levels of bradykinin in the

lungs, so the cough which is a common side effect of ACE inhibitors does not occur with ARBs.

Other side effects of ARBs, such as angioedema, altered renal artery perfusion, and lowered

effectiveness in African-Americans, are similar to those of ACE inhibitors.

What are the main actions on arteries by ARBs?

Vasodilation and increased peripheral vascular resistance

Vasodilation and decreased peripheral vascularresistance

Vasoconstriction and increased peripheral vascular resistance

Vasoconstriction and decreased peripheral vascular resistance

ARBs help prevent which action?

Release of sodium

Release of bradykinin

Release of aldosterone

Absorption of aldosterone

What effect do ARBs have on the excretion ofsodium and water?

Increase excretion of sodium and water

Decrease excretion of sodium and water

Increase excretion ofsodium and decrease excretion of water

Decrease excretion ofsodium and increase excretion of water

• When caring for patients taking ARBs, the nurse should obtain baseline blood pressure

and regularly monitor blood pressure throughout therapy. The target blood pressure is

140/90 mm Hg or lower in most patients and 130/80 mm Hg in patients with diabetes.

• Patients should report shortness of breath, dizziness, and unusual fatigue immediately.

• Patients with heart failure should be monitored for a decrease in symptoms.

• Patients with diabetic nephropathy should be monitored for proteinuria and alterations in

GFR.

• ARBs are contraindicated in patients with a known drug allergy to ARBs. Patients with a

history of angioedema when taking ACE inhibitors should not take ARBs, even though

the risk of angioedema is lower with ARBs. Patients who develop a wheal and flare rash