ONS ONCC Chemo Renewal
Study online at https://quizlet.com/_3t82fe
1. Neoadjuvant therapy does not increase
survival when compared to adjuvant
therapy. It only changes the timing of
treatment and can change surgical options if the tumor is shrunk enough. If
this occurs, the patient may only require
a lumpectomy plus radiation therapy instead of needing a mastectomy
Main benefit of neoadjuvant
chemotherapy (breast cancer
patient)
2. A comprehensive geriatric assessment
(CGA) is a multidisciplinary evaluation
to assess life expectancy and risk of
morbidity and mortality in the older patient. This assessment tool would
evaluate and include the following areas: functional status, socioeconomic
issues, psychosocial distress, comorbidities, cognitive function, nutritional
status, polypharmacy, and a medication review (NCCN Older Adult Oncology
Guidelines, version 1.2015).
Due to Mrs. Turner's age and comorbidities, her oncologist performs a comprehensive geriatric
assessment. You know that this
assessment covers all but which
of the following:
3. 65 The NCCN Older Adult Oncology Guidelines (version 1.2015)
provides information on what
is included in a comprehensive
geriatric assessment. Currently,
more than 60% of cancers in the
United States occur in people
age ______and older and as the
oncology world ages, nearly half
(46%) of cancer survivors are 70
years of age or older
4. Two of the agents (docetaxel and carboplatin) that Mrs. Turner will receive
are categorized as irritants. Docetaxel
can cause a significant reaction if it extravasates. It can lead to edema, erytheWhat is your best explanation for
why Mrs. Turner was given a port
to receive her chemotherapy?
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ONS ONCC Chemo Renewal
Study online at https://quizlet.com/_3t82fe
ma, occasional pain and blister formation (ONS Chemo/Bio guidelines, 2014).
That is the most likely reason that Mrs.
Turner was given a port for her treatments. Some patients will receive their
treatments through a peripheral IV without incident. Just because they are intravenous agents does not mean that a
port is required and needing a port has
nothing to do with her being older in
age. Since none of these agents are vesicants, they likely could have been given
safely via peripheral route but having a
port placed is OK as well.
5. Irrirtants _____________can cause inflammation, pain, and burning
but rarely cause tissue necrosis
comparable to a vesicant (unless
a large amount or a very high
concentration of the irritant is extravasated).
6. Vesicants _____________can cause blistering and significant pain and
tissue damage and destruction,
leading to tissue death.
7. Non-DNA-binding solutions remain in
the local area of the extravasation, which
improves the possibility of drug deactivation.
DNA-binding agents attach to DNA nucleic acids, causing the antagonist to be
ingested cellularly, leading to progressive tissue destruction
A further classification of an antineoplastic agent's potential to
cause damage is whether its
mechanism of action includes
DNA binding.
8. Bendamustinea
Dactinomycin
Daunorubicin
DNA Binding Irritants
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ONS ONCC Chemo Renewal
Study online at https://quizlet.com/_3t82fe
Doxorubicin
Epirubicin
Idarubicin
Mechlorethamine
Mitomycin
9. Amsacrine
Paclitaxel
Vinblastine
Vincristine
Vindesine
Vinorelbine
DNA Nonbinding vessicants
10. Sodium thiosulfate
Inject 2 ml of sodium thiosulfate for each
milligram of
mechlorethamine extravasated.
Inject subcutaneously into extravasation
site using a 25
gauge or smaller needle (change needle
with each injection).
Monitor extravasation site according to
the institution's
policies and procedures.
Extravasciation Alkylating /
Mechlorethamine tx
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