Contents I. General 3 II. Autonomic Adrenergic Drugs 19 Cholinergic Drugs 26 Autacoids 33 III. Renal 37 IV. CVS 44 V. Blood 57 VI. Endocrine 67 VII. General Chemotherapy 77 VIII. Special Chemotherapy 88 IX. GIT _ 93 X.CNS XI. Nonsteroidal Anti-inflammatory Agents 114 XII. Respiration XIII. Miscellaneous 99 117 124 XIV. Problem Solving 132 he following areTrue concerning diffusion of drugs across cell membranes EXCEPT: A. Most drugs cross cellmembranes primarily by passive diffusion. B. Diffusion depends on lipid-solublity. C. Acidification of urine hastens excretion ofweakly acidic drugs. D. Aspirin is mostly non-ionized inthe empty stomach. E. Drugs can cross cellmembrane mainly in non-ionized form. 2. Important factor/s which may govern diffusion of drugs across cell membranes A. pKa value ofthe drug B. pH ofthe medium C. Lipid solubility ofthedrug D. Molecular weight of the drug E. All ofthe above 3. Which ofthe following statements is/are True? A. Bioavailability after oral administration is determined by hepatic extraction ratio B. Dialysis isusefiil intoxicity of drugs with large volume ofdistribution C.Propranolol increases hepatic first pass metabolism. D. Drugs with variable bioavailability include digoxin &phenytoin. E. A&D 4. Which of the following isa True statement? A. Acetylation is a phase I reaction B. Theophylline is adrug with saturation kinetics and narrow therapeutic index C. Aconstant amount ofadrug with 1ST -order kinetics is eliminated per unit time. D. Steady-state plasma concentration ofdrugs with zero-order kinetics isachieved after 4 E. The first-pass effect is most likely to occur ifthe drug is given sublingually. -3- 5. Drug/s reducing hepatic 1st pass metabolism is/are: A. Rifampicin C. Erythromycin B. Propranolol D. Band C E. All ofthe above 6. Clearance is useful in calculation of A. Maintenance dose. D. Bioavailability B. Loading dose. E. Aand C. C. t1/2. 7.Which ofthe following is a True statement concerning drug clearance? A. Clearance is useful in calculation ofloading dose. B. When extraction ratio is less than 0.2 its clearance is nearly enzyme-dependent C. ItisinverselyjM-oportional to the blood flow to the clearing organ. D. Lipid solubility increases renal excretion of drugs. E. It is directly proportional to volume of distribution 8. Amain determinant of bioavailability (F) following oral administration is A. Hepatic extraction ratio(E) B. Elimination rate constant (Ke) C. Bioequivalence D. Volume of distribution E. All ofthe above 9. Lipophilicity reduces A. Absorption^ B. Volume of distribution (Va) C. Hepatic elimination D. Renal excretion E.BandD