1. What is the primary mechanism of action for SSRIs in the treatment of depression? - A) Blockade of dopamine receptors - B) Inhibition of monoamine oxidase - C) Reuptake inhibition of serotonin - D) Increase in norepinephrine secretion Answer: C) Reuptake inhibition of serotonin Rationale: SSRIs, or selective serotonin reuptake inhibitors, function primarily by blocking the reabsorption (reuptake) of serotonin in the brain, making more serotonin available to improve transmission of messages between neurons. 2. Which pharmacokinetic process is most affected by liver disease? - A) Absorption - B) Distribution - C) Metabolism - D) Excretion Answer: C) Metabolism Rationale: The liver is the primary site for drug metabolism. Liver disease can significantly impair the metabolism of drugs, leading to increased drug levels and potential toxicity. 3. What is the significance of the blood-brain barrier in pharmacodynamics? - A) It prevents all drugs from entering the brain. - B) It selectively allows lipid-soluble drugs to pass into the brain tissue. - C) It actively transports drugs out of the brain. - D) It has no role in drug action. Answer: B) It selectively allows lipid-soluble drugs to pass into the brain tissue.