Chapter 01: Cellular Biology......................................................................................................................... 4 Chapter 02: Altered Cellular and Tissue Biology: Environmental Agents .................................................. 18 Chapter 03: The Cellular Environment: Fluids and Electrolytes, Acids and Bases ..................................... 31 Chapter 04: Genes and Genetic Diseases .................................................................................................. 44 Chapter 05: Genes, Environment-Lifestyle, and Common Diseases.......................................................... 55 Chapter 06: Epigenetics and Disease......................................................................................................... 63 Chapter 07: Innate Immunity: Inflammation and Wound Healing ............................................................ 68 Chapter 08: Adaptive Immunity................................................................................................................. 83 Chapter 09: Alterations in Immunity and Inflammation............................................................................ 95 Chapter 10: Infection ............................................................................................................................... 108 Chapter 11: Stress and Disease................................................................................................................ 117 Chapter 12: Cancer Biology...................................................................................................................... 124 Chapter 13: Cancer Epidemiology............................................................................................................ 137 Chapter 14: Cancer in Children................................................................................................................ 143 Chapter 15: Structure and Function of the Neurologic System ............................................................... 148 Chapter 16: Pain, Temperature Regulation, Sleep, and Sensory Function .............................................. 159 Chapter 17: Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function............... 174 Chapter 18: Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction .................................................................................................................................................................. 188 Chapter 19: Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders........................... 199 Chapter 20: Alterations of Neurologic Function in Children.................................................................... 206 Chapter 21: Mechanisms of Hormonal Regulation.................................................................................. 213 Chapter 22: Alterations of Hormonal Regulation .................................................................................... 222 Chapter 23: Obesity and Disorders of Nutrition ...................................................................................... 234 Chapter 24: Structure and Function of the Reproductive Systems.......................................................... 239 Chapter 25: Alterations of the Female Rep