A provider prescribes phenobarbital for a client who has a seizure disorder. The medication has a long half-life of 4 days. How many times per day should the nurseexpect to administer this medication?

A. One B.

Two C.

Three

D. Four-ANSWER-A. One

(Medications with long half-lives remain at their therapeutic levels between doses for long periods of time. The nurse should expect to administer this medication once a day.)

A staff educator is reviewing medication dosages and factors that influence medicationmetabolism with a group of nurses at an in-service presentation. Which of the followingfactors should the educator include as a reason to administer lower medication dosages? (Select all that apply.)

A. Increased renal secretion

B. Increased medication-metabolizing enzymesC. Liver

failure

D. Peripheral vascular disease

E. Concurrent use of medication the same pathway metabolizes - ANSWER-C. Liverfailure

E. Concurrent use of medication the same pathway metabolizes

C. Liver failure decreases metabolism and thus increases the concentration of amedication. This requires decreasing the dosage.

E. When the same pathway metabolizes two medications, they compete for metabolism, thereby