1. Which organ is most commonly targeted by metastasis? A. Liver B. Kidney C. Pancreas D. Lungs Answer: A. Liver Rationale: The liver is the most common site for metastasis due to its rich blood supply and ability to filter blood from multiple organs. 2. Metastasis to the lungs most commonly originates from which primary cancer site? A. Breast B. Prostate C. Colon D. Skin Answer: A. Breast Rationale: Breast cancer is known to frequently metastasize to the lungs, making it the most common primary cancer site for lung metastasis. 3. Bone metastasis is often seen in patients with which primary cancer? A. Lung B. Prostate C. Brain D. Pancreas Answer: B. Prostate Rationale: Prostate cancer commonly metastasizes to the bones, particularly the spine, pelvis, and ribs. 4. Metastasis to the brain is more likely to occur in patients with which primary cancer? A. Breast B. Colon C. Liver D. Kidney