1. Multiple Choice: Which of the following mechanisms is primarily involved in the development of anemia of chronic disease? A) Increased erythropoietin production B) Decreased iron availability for erythropoiesis C) Increased iron excretion D) Decreased erythrocyte destruction Answer: B) Decreased iron availability for erythropoiesis Rationale: In anemia of chronic disease, inflammatory cytokines lead to increased hepcidin levels, which block iron release from macrophages and decrease iron absorption, reducing iron availability for erythropoiesis. 2. True/False: The primary pathophysiological feature of asthma is reversible airway obstruction. Answer: True Rationale: Asthma is characterized by reversible airway obstruction due to bronchial hyperresponsiveness and inflammation leading to bronchoconstriction.