50% of liver disease in the US is directly related to alcohol consumption; of the estimated 15 million alcoholics in the USA 10-20% have or will develop this; growing number of cases related to chronic hepatitis C; a chronic progressive disease of the liver; extensive parenchymal cell degeneration; destruction of parenchymal cells? {{Ans- cirrhosis Etiology and pathophysiology of cirrhosis: cell necrosis occurs; destroyed liver cells are replaced by _______; normal architecture becomes nodular? {{Ans- scar tissue Etiology and pathophysiology of cirrhosis: associated with alcohol abuse; preceded by a theoretically reversible fatty infiltration of the liver cells; widespread scar formation; nonalcoholic fatty liver disease (NAFLD); complication of toxic or viral hepatitis; broad bands of scar tissue form within the liver? {{Ans- chronic liver disease Etiology and pathophysiology of cirrhosis: associated with chronic biliary obstruction and infection; accounts for 15% of all cases of cirrhosis? {{Ans- biliary cirrhosis Etiology and pathophysiology of cirrhosis: results from longstanding severe right-sided heart failure? {{Ans- cardiac cirrhosis Five major functions of the liver? {{Ans- 1) drug metabolism & detoxification 2) metabolic (fat, carbohydrate, & protein metabolism; vitamin/mineral absorption) 3) blood volume reservoir 4) blood filter 5) production of blood clotting factors