Neurotransmitter Table

* To be completed throughout course and submitted in Week 8*

Neuro

transmitter

Receptor

Subtype

Location/Function/Effects

/symptoms of excess or

deficit if applicable

Distribution

(ie: CNS/PNS,

GI, vascular)

Drug classes that

target this

neurotransmitter or

receptor

Specific medicationsthat target this

neurotransmitter or receptor

Glutamate AMPA α-Amino-3-hydroxy-5-

methyl-4-

isoxazolepropionic acid

(AMPA)-type glutamate

receptors (AMPARs)

mediate the majority of

fast excitatory synaptic

transmission in the brain.

AMPA receptors are

abundant and widely

distributed in the central

nervous system.

Hippocampus, outer layer

of the cortex, basal

ganglia, olfactory regions,

lateral septum, and

amygdala of the CNS are

all enriched with GluA1,

GluA2, and GluA3

subunits.

CNS AMPA Receptor

Antagonists

Perampanel

MNDA N-methyl-D-aspartate

(NMDA) receptors

represent one of the

ligand-gated non-selective

ionotropic glutamate

receptors(iGluRs), which

CNS

NMDA receptors

are found in

both synaptic

and

extrasynaptic

NDMA Glutamate

Antagonist

NDMA Glutamate Antagonist-

Memantine

Phencyclidine

Ketamine

Dextromethorphan

Dextromethadone

are present in high density

within the hippocampus

and the cerebral cortex

N-methyl-D-aspartate

(NMDA) receptors, a

family of L-glutamate

receptors, play an

important role in learning

and memory, and are

critical forspatial memory

demonstrated

deterioration in NMDA

receptor subunit

expression and function

with advancing age

locations on

neurons. NMDA

receptors also

can be found on

neurons in early

stages prior to

synaptogenesis,

where they may

be involved in

migration and

differentiation.

Extrasynaptic

NMDA receptors

typically are

associated with

contacts with

adjacent

processes such

as axons and

glia

GABA GABA a Limbic system

GABAa is considered in

fastsynaptic inhibition.

GABAa

receptors are

located

throughout the

central nervous

system

Benzodiazepines

Neuroactive Steroids

Zolpidem

Zaleplon

Zopiclone

Eszopiclone

Allepregnanolone

Serotonin

5HT

5HT 1a 5HT1A receptors are

located on GABA

interneurons in the

prefrontal cortex

5HT1A receptors can

promote the release of

CNS partial 5-HT1A-R

agonists

buspirone, gepirone, and

tandospirone