1. Multiple Choice: Which research design is most appropriate for establishing causality? a) Cross-sectional b) Cohort c) Randomized Controlled Trial (RCT) d) Case-control Answer: c) Randomized Controlled Trial (RCT) Rationale: RCTs are considered the gold standard for establishing causality because they eliminate confounding variables through random assignment. 2. True/False: Peer-reviewed articles are the only sources of evidence that should be used in evidence-based practice. Answer: False Rationale: While peer-reviewed articles are a key component of evidence-based practice, other sources such as patient preferences, clinical expertise, and quality improvement data also play a crucial role.