1. While rational drug selection is based on individual patients’ aspect of rational drug selection addressing disease specific information by a national medical or nursing organization is Guidelines 2. Drugs that alter synaptic transmission are much more selective than those alter axonal conduction – why? Axonal conduction – nonselective effect Synaptic transmission – very selective because of the differences in synapses and their specific neurotransmitters 3. Phenytoin used for? Seizures 4. What should we monitor with Phenytoin? Delayed hypersensitivity reaction – even after 1 month 5. Carbamazepine used for? Seizures 6. What may cause carbamazepine levels to drop despite no other changes? Auto metabolization of drug – increase dose to get effect Check serum drug levels 7. Black box warning for carbamazepine? Steven Johnson syndrome and TENS 8. Monitoring for carbamazepine, how often? CBC –