Chapter 1: Pharmacokinetics and Routes of Administration

• Absorption

▪ Route of admin affects the rate and amount of absorption

o Oral:

▪ GI pH and emptying time

▪ Presence of food in the stomach or intestines

▪ Form of meds (liquid/XR)

o Sublingual/buccal

▪ Quick absorption systemically through highly vascular mucous

membranes

o Inhalation via mouth/nose

▪ Rapid absorption through alveolar capillary networks

o Intradermal, topical

▪ Slow, gradual absorption

o SQ/IM

▪ Highly soluble meds have rapid absorption (10-30min), poorly soluble

have slower absorption

▪ Blood perfusion at site of injection affect absorption

o IV

▪ Immediate and complete

• Distribution

o Transportation of meds to sites of action by body fluids

o Plasma binding protein: meds compete for protein binding sites within

bloodstream, primarily albumin. The ability of med to bind to protein can affect

how much med will leave and travel to target tissues.

• Metabolism

o Primarily occurs in the liver but can take place in the kidney