A 65-year-old man presents to the office with increased frequency, urgency, nocturia, and hesitancy in micturition for the past week. He also complains of pain in ejaculation. He has no flank pain, dysuria, hematuria, or fever. He is in a monogamous relationship and uses condoms regularly. His temperature is 98.6 F (37 C), pulse rate is 77 beats/ minute, respiration is 14 breaths/minute, and blood pressure is 130/80 mmHg. There is no costovertebral angle tenderness or suprapubic tenderness, and external genitalia examination is normal. Digital rectal examination shows normal sphincter tone and reflexes with slightly enlarged and tender prostate. Urinalysis shows many WBCs with no RBCs or casts. Urine culture grows E. coli. Serum prostate-specific antigen is 8ng/mL (reference range of less than 3.5 ng/mL). Which of the following drug class can be used to treat the patient's condition? fluroquinolone A 41-year-old G5P4004 at 38 weeks, 0 days pregnant presents for late prenatal testing. She is found to have IgM-positive antibodies for HSV-2. The patient desires to deliver vaginally. Which of the following statements is correct regarding the treatment of choice for this patient's condition? it is generally safe in pregnancy A 25-year-old woman presents to the clinician with complaints of frequent burning micturition and suprapubic discomfort from the past two days. The patient is sexually active and has no significant past medical history. Urinalysis reveals the presence of leukocyte esterase and a high level of nitrites. The clinician prescribes her a combination antibiotic that inhibits two steps in the bacterial biosynthesis of tetrahydrofolate. Which of the following is a contraindication to the use of this medication? pregnancy A 35-year-old woman comes to the office for pain and burning during urination for the past few days. She denies fever, abdominal or flank pain, bloody urine, or passing any stones while urinating. She has a medical history of gastroesophageal reflux disease, diabetes mellitus type 2, and hyperlipidemia. She takes over-the-counter antacids, pantoprazole, metformin, and atorvastatin. She is para 2 with both normal vaginal delivery and her last menstrual period was three weeks ago. She uses oral contraceptive pills for contraception. Her temperature is 37.2 C, her pulse is 70 beats/min, her respiratory rate is 12 breaths/min, and her blood pressure is 130/80 mmHg. On examination, she denies suprapubic pain or costovertebral angle tenderness. Urinalysis reveals white blood cells of 20-25/hpf and red blood cells of 510/hpf with no casts. Urinary nitrites and leukocyte esterase are positive, and glucose and ketone are absent. White blood cell count is 7800/mm3. Serum creatinine is 1.1 mg/dL and blood urea nitrogen is 17 mg/dL. Urine culture grows Escherichia coli. The patient is started on a drug that inhibits an enzyme required in bacterial DNA replication. The patient is