Neurotransmitter Table * To be completed throughout course and submitted in Week 8* Neuro transmitter Receptor Subtype Location/Function/Effects /symptoms of excess or deficit if applicable Distribution (ie: CNS/PNS, GI, vascular) Drug classes that target this neurotransmitter or receptor Specific medicationsthat target this neurotransmitter or receptor Glutamate AMPA α-Amino-3-hydroxy-5- methyl-4- isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. AMPA receptors are abundant and widely distributed in the central nervous system. Hippocampus, outer layer of the cortex, basal ganglia, olfactory regions, lateral septum, and amygdala of the CNS are all enriched with GluA1, GluA2, and GluA3 subunits. CNS AMPA Receptor Antagonists Perampanel MNDA N-methyl-D-aspartate (NMDA) receptors represent one of the ligand-gated non-selective ionotropic glutamate receptors(iGluRs), which CNS NMDA receptors are found in both synaptic and extrasynaptic NDMA Glutamate Antagonist NDMA Glutamate AntagonistMemantine Phencyclidine Ketamine Dextromethorphan Dextromethadone are present in high density within the hippocampus and the cerebral cortex N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an important role in learning and memory, and are critical forspatial memory demonstrated deterioration in NMDA receptor subunit expression and function with advancing age locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation. Extrasynaptic NMDA receptors typically are associated with contacts with adjacent processes such as axons and glia GABA GABA a Limbic system GABAa is considered in fastsynaptic inhibition. GABAa receptors are located throughout the central nervous system Benzodiazepines Neuroactive Steroids Zolpidem Zaleplon Zopiclone Eszopiclone Allepregnanolone Serotonin 5HT 5HT 1a 5HT1A receptors are located on GABA interneurons in the prefrontal cortex 5HT1A receptors can promote the release of CNS partial 5-HT1A-R agonists buspirone, gepirone, and tandospirone