1. What is the primary mechanism of action for beta-blockers like
propranolol in the treatment of hypertension?
A. Vasodilation
B. Beta-adrenergic antagonism
C. Diuresis
D. Calcium channel blockade
Correct Answer: B
Rationale: Beta-blockers work by blocking the effects of epinephrine
(adrenaline) on the beta-adrenergic receptors, which reduces heart rate
and cardiac output, leading to a decrease in blood pressure.
2. Which phase of drug metabolism is primarily responsible for the
introduction of polar groups into the drug molecule?
A. Phase I
B. Phase II
C. Phase III
D. Phase IV
Correct A
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